Linker diversity

Linker design provides for great flexibility with respect to half-life engineering, polymer and drug compatibility. Through variation of activation chemistry and conjugation sequence, various combinations of polymer carriers and drug compounds are accessible.

Control elements of linker cleavage kinetics

Strudture-activity relationsships were determined for a family of six linkers:

• Reversible linker reagents
• Linker diversity
• Transient PEGylation