Reversible linker reagents

Fundament for Ascendis Pharma's chemically controlled delivery approach is a group of unique and proprietary reversible linker reagents in contrast to cleavable linkers used for instance in cancer therapy, the Complex group of linkers are specifically designed to slowly autohydrolyse at a predictable rate linkers self-cleave according to high-precision kinetics in the blood, under the skin or in the intestine linker cleavage does not depend on the presence of certain enzymes or intracellular conditions such as reducing or acidic environment

• Reversible linker reagents
• Linker diversity
• Transient PEGylation