Transient PEGylation

Transient PEGylation is a molecular engineering technology proprietary to Ascendis Pharma.

The approach affords high-precision pharmacokinetics for biotherapeutics through chemically controlled, slow-release of drug from a well-tolerated carrier polymer (polyethylene glycol, PEG).

TransPEG conjugates have all the benefit of the drug´s original pharmacology while exhibiting a long-acting highly optimized pharmacokinetic profile.

• Reversible linker reagents
• Linker diversity
• Transient PEGylation